Numbers help
How do I change the default font in Numbers so it will always be my preferred font when I create a new sheet?
iPad Pro, iPadOS 15
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You could start a new document, change the fonts in it to the ones you like, and then File > Save as Template... and give it a name.
Then when you start a new document in the future via File > New just choose that saved template.
It will be in the My Templates section and, if you've used it recently, also in Recents.
SG