warner505, that's interesting to hear that. I know how it feels...
I have just posted a similar question about an external Lacie drive dismounting in sequoia 15.7. This is also the only spinning drive I have that is formatted in APFS. None of my HFS+ formatted spinning drive RAIDS are having issues. In my case, a new Lacie 2 Big Dock is dismounting in 15.7 but my old ones are working fine. To add to the confusion, all my external drives seem to mount OK in Tahoe using an external boot SSD. But I want to test that over a longer time frame before proceeding with Tahoe, or wait for the first revision to arrive.
Can I ask:
How many of your Lacie drives are APFS formatted?
How many of your drives contain Time Machine backups?
Have you tried a safe boot or a ‘test’ account yet?