Apple Mail - Application Not Responding

DMANITALY wrote:

I am using Big Sur 11.6. Every so often, my Apple Mail (14.0) application will simply not start.

I see the Apple app bounce at the Dock, the Menu shows at first, I get a beach ball, then Activity Monitor shows Not Responding.

I've tried:

Shift Open the App (from the Dock and within Applications)

Safe Mode App Opening

PRAM Reset

Restoring the OS

Nothing works now.

Any ideals on removing .plists or pref files?

I could really use the assistance!!

If it launches in your Safe Boot...this would be telling. SafeBoot https://support.apple.com/en-us/HT201262

Try Uninstall all third party apps that are Cleaners/Optimizers/Anti-Virus/VPN

if no resolve—

You can get a good look at your System config. and reveal conflicts or issues, you can download/run this trusted utility https://etrecheck.com

If you need help interpreting the report you can post it here in its entirety in the "Additional Text" box in the editing toolbar below, in your reply.