Can I use Homepod mini with my Mac?

In case you were thinking you might be able to use HomePod with a Mac and no other Apple hardware note that an iOS device is required to set up HomePod. From HomePod - Technical Specifications:

System Requirements

• iPhone SE, iPhone 6s or later, or iPod touch (7th generation) with the latest iOS; or iPad Pro, iPad (5th generation or later), iPad Air 2 or later, or iPad mini 4 or later with the latest iPadOS
• 802.11 Wi-Fi Internet access

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Use HomePod with Mac - Apple Support