Obviously this is not expected behavior but right now you are the only one reporting this so it’s not likely a bug in Sequoia. I would recommend restarting your Mac into “Safe Mode” which often resolves glitches like this.
Start up your Mac in safe mode - Apple Support
This can take considerably longer than a normal startup so be patient. After entering safe mode check to see if your System Settings are present, then restart your Mac in normal mode. See if the issue is resolved.
When restarting in safe mode certain maintenance tasks are performed and certain caches are emptied.