Make sure the EHD is formatted APFS or OS X Extended (journaled) or you will damage the library.
As it takes a while for Photos to detect and show duplicates you may want to be a bit more proactive and use one of these two dup finding apps on your library:
You want an app that will identify the potential duplicates, put them in an album or mark them with a keyword for easy retrieval and deletion by you. You don't want one that does the deletion itself for obvious reasons.
I've run tests on the these two apps with the following results and found them to be safe to use:
PowerPhotos - $30
PowerPhotos is the iPhoto Library Manager version for Photos and is very powerful. Although more expensive I would recommend it as it has more capabilities than the others like the capability to merge Photos libraries or copy photos, both original and edited versions, along with their metadata between libraries.
PhotoSweeper - $15 - Demo version available.
PhotoSweeper compares bitmaps and/or histograms so it can detect duplicate images even if they have different file sizes, file names, image sizes and capture dates.
FWIW PowerPhotos is the more powerful Photos library utility available. Besides find duplicates it can merge libraries, view libraries without opening them and in columnar format showing and sorting by size, type, etc.
Just some food for thought.
