Yeah, that Hard Drive is just starting to fail with 22 reallocated sectors.
Currently there are no pending sectors awaiting reallocation (attribute # 197) which is good, but that doesn't mean that there may be some other sectors that may be having trouble being read that have not reached the point of complete failure of the sector.
I have never seen how fast the Hard Drive failures progress since either the drives are so bad, or they are just starting to fail like this one & I replace them so the user doesn't have to worry. You may want to perform a Disk Utility First Aid scan on the file system of the hidden APFS Container to see if any errors need to be repaired. Within Disk Utility you may need to click "View" and select "Show All Devices" before the hidden Container appears on the left pane of Disk Utility.....selecting the "Fusion Drive" item may also be a good idea. Even if First Aid says everything is "Ok", click "Show Details" and scroll through the report to see if any unfixed errors are listed. If there are errors, then run First Aid again until they are gone. If after several scans the errors remain, then try running First Aid while booted into Recovery Mode.
Then run another EtreCheck report after the First Aid scan runs clear now that you uninstalled the suspect software to see if the performance of the Fusion Drive has improved and by how much. And to ensure that all of the remnants of those uninstalled apps are completely gone....sometimes pieces of them may remain behind.
If the speed & performance improves, then you may want to monitor the health of the internal Hard Drive to see if any more Reallocated Sectors/Events occur and whether there is a change in the "Current Pending Sector Count". However, you should be planning on how to deal with the failing Hard Drive. Would you prefer to spend money to have the iMac repaired to replace the internal Hard Drive, or rather use an external USB3 or Thunderbolt2 SSD instead? An USB3 SSD would have a maximum speed of about 400-500MB/s due to the limited 5Gb/s USB3 port while a Thunderbolt2 SSD could potentially reach speeds up to 40Gb/s or about 5GB/s (5,000MB/s) depending on the SSD.