Thank you for the new report. I take it that even without the external drives connected there is still a slowdown.
This is the only thing that I can see that looks like it could play a part in it:
App Extensions:
Finder sync extensions:
[Loaded] Adobe Content Synchronizer Finder Extension - /Applications/Utilities/Adobe Sync/CoreSync/Core Sync.app
[Loaded] Adobe Context Menu Extension - /Library/Application Support/Adobe/Adobe OS Extension/Creative Cloud.app
Note that I don't have Adobe software, and I am not familiar with their particular Finder sync extensions.
Finder sync extensions are meant to allow the user to treat cloud storage in a way that is identical to local storage.
They are used by the likes of dropbox, onedrive, googledrive.
It is possible that the inherent latency in accessing cloud content may be what is impacting your open and save actions.