You have a lot of "stuff" running. Adobe and google products tend to be resource hogs.
You also have a lot of extensions installed, many of which are obsolete. silverlight jumps out at me right away. That was deprecated by Microsoft years ago.
I would strongly consider backing up your data, and wiping the machine, reinstalling macOS, to start from scratch.
It's possible there is an impending hardware failure, but I'm guessing the issues are software related, possible due to old system modifications and kernel extensions, at least some of which you no longer need and may have been inherited from even older machines if you migrated from an older machine to the one you have now.
I would also suggest starting to plan for replacing this machine in the not too distant future. Though it can run Tahoe, Tahoe will be the end of the line for OS upgrades for an intel based Mac.