Your ask is essentially out of scope for the support provided in the Apple Support Communities and may be better asked on the Apple Developer forums.
That said, I strictly install Python3 from Python.org. I create a Python3 virtual environment where I install the latest compatible PySide6 from the Qt for Python Project. See the version matrix at that link for PySide6 and Python3 compatibility.
Qt Creator 18.0.1 is a Universal2 (ARM64/X86_64) binary though whether it is fully compatible and built against macOS Tahoe is unknown. Select Qt Creator category from the Offline Qt Downloads page, and then the Qt Creator 18.0.1 for macOS. Because it is unsigned, you may need to visit System Settings > Privacy & Security > Security to install it anyway. That will be evident if the Qt Creator installer refuses to install because it is an unknown developer.
Other info:
https://www.pythonguis.com/tutorials/pyside6-first-steps-qt-designer/
https://www.pythonguis.com/pyside6-tutorial/