The "Load Cycle Count" on the hard drive is way past its maximum expected value which means the drive is wearing out. The SSD in the Fusion Drive setup is masking the drive's poor health and worn out state. The hard drive could very well be contributing to some of the problems. Even if the hard drive is working Ok now, it won't be for very much longer. I would suggest disabling "Put hard disk to sleep when possible" which is located in the Energy Saver System Preferences as it may help to extend the drive's life a bit.
The SSD appears to be Ok.
As far as the software you should uninstall Webroot, Clean My Mac, and Virus Barrier by following the developers' instructions. Anit-virus and cleaning apps are not needed on a Mac and usually cause more problems than they solve. Plus they impact system performance. Even if you want to use an anti-virus app you should only ever install one app since they will be competing with each other making the system even more slow and unstable. MalwareBytes is acceptable if you feel the need to use it as MalwareBytes is the only one which really works on a Mac.
Your computer is also running out of memory so uninstalling those items should help somewhat. I would suggest disabling the automatic launching of some other items to help free up some memory as well. There are some other apps I am unsure about, but uninstalling the AV & cleaning apps is a good start to see how much it improves your computer. If you still have problems, then run EtreCheck again after removing those items mentioned and post it here so that some other more knowledgeable contributors can comment on the report.
I would highly recommend re-enabling the Security updates to help keep your system safe. Security updates should rarely interfere with your system or apps.
