The "runtime" issue is just that on a modern Mac with a SSD, most people would expect EtreCheck to run and get to spitting out it's report in 3:00 or so. Almost 6:00 is slow. But it does depend on a number of factors - including the age of your Mac. For example, I still have a 2012 MacBook Pro running Catalina that I use for certain things. Sure I replaced the HDD with a SSD ages ago - but a 2012 MacBook Pro with a SATA SSD is never going to be as fast as any 2020's era M-series Mac with a NVMe SSD attached directly to the logic board.
Your system actually isn't that bad. The main issue I see is some "partially uninstalled" software and related leftover crud in your launch agents and daemons.
Quick aside - daemons are programs that run completely in the background. Agents are background programs that you interact with (they pop up dialog boxes and so on). You only have LaunchAgents in your home folder at /Users/<your name>/Library/LaunchAgents (sometime abbreviated as ~/Library/LaunchAgents). There is a folder for each in the root Library at /Library
You mentioned already removing Clean My Mac - did you follow the developer's uninstall instructions? If not, things like the LaunchAgents/LaunchDaemons can get left behind, and still try to run.
CCleaner is similarly useless.
You have two VPNs (or had at least since they seem to be partially uninstalled). Lots of people will say you don't any - but I also see a PT.updd.plist entry in one of your screenshots, which I believe is for Popcorn Time - so I assume you use a VPN for changing your geolocation to unlock content. In which case I would say to find a VPN that is lightweight and easy to uninstall (e.g., I believe Surfshark and NordVPN both have App Store versions).
Similarly for Anti-malware, although Avast isn't the worst when it comes to consuming system resources and performs well against the Virus Total tests. And you seem to use Microsoft Office, so there can be a valid use case for them if rountinely sharing files with colleagues on Windows.
Again, though, much of your Microsoft products are in that "partially uninstalled" list. So you may want to reinstall and uninstall some things - according to the developer's instructions, or at least use those "review" buttons in Etrecheck to find and/or delete the files.
