Cannot save Screenshot

You may try and see if Safe mode can help on startup; takes awhile.

Then restart without shift-key held, to return to normal use.

• How to use Safe mode on your Mac - Apple Support

https://support.apple.com/en-us/HT201262

Another thing to try, may be SMC reset. Instructions vary due to a

wider field of intel-based Macs it caters to. (M1 hasn't a need.)

• How to reset the SMC of your Mac - Apple Support

https://support.apple.com/en-us/HT201295

Further, you may need to consider start up into macOS Recovery;

maybe use to run disk utility; or perhaps reinstall the macOS?

• About macOS Recovery on Intel-based Mac computers - Apple Support

https://support.apple.com/en-us/HT201314

ZotMan49 wrote:

Using Catalina, v10.15.7 When I take a screenshot (command-shift-4) I get a popup that says:

:Your screenshot can’t be saved. Cannot write file to intended destination.

Mac OS Catalina v 10.15.7 (19H1217)

"MacBook Pro13-inch Mid 2012)

 Model Identifier: MacBookPro9,2

 Processor Name: Dual-Core Intel Core i5

 Processor Speed: 2.5 GHz

 Number of Processors: 1

 Total Number of Cores: 2

 L2 Cache (per Core): 256 KB

 L3 Cache: 3 MB

 Hyper-Threading Technology: Enabled

 Memory: 16 GB

 Boot ROM Version: 421.0.0.0.0

 SMC Version (system): 2.2f41

Uninstall all third party apps that are Cleaners/Optimizers/Anti-Virus/VPN