I updated my Mac to the Monterey and several things now do not work. My mouse doesn't scroll and the system preferences won't even come up. Should I go back an update and if so, how do I do that?

If the Safe Mode startup does not help, then please do the following:

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Hello, sheryll66.

I'm sorry that you're having this trouble with the Mac.

I would only consider downgrading the OS if you cannot find a remedy otherwise. Downgrading is not trivial and will require that you wipe the internal drive and reinstall the OS from recovery mode. This is a last resort. You'll need to ensure first that you have a current Time Machine or other backup of your Mac and user data.

Instead, try this first.

If rebooting your Mac doesn’t fix things, see if the problem still happens in Safe mode (hold the shift key down at startup). It can take much longer to safe boot (10 min) so be patient.

How to use safe mode on your Mac - Apple Support 

Safe mode disables loading third-party drivers, forces the OS to clear certain caches and logs and does other miscellaneous housekeeping. It's non-destructive to user data so is safe to do. Very often certain weird software behavior is corrected by simply logging in this way as a troubleshooting method. When you're in safe boot, the machine will not be at its best performance, especially with graphics, but that's expected.

Does the problem persist while in Safe mode?

Exit safe mode by restarting your Mac normally and re-evaluate the issue again.

Also, ensure that you have no anti-virus, clean up or optimizing applications installed. These will very often interfere with the proper operation of macOS and cause more trouble than they claim to prevent. If you have these types of software, uninstall them per the developer's instructions, restart the Mac and see if the problem is resolved.

XProtect Explained: How Your Mac’s Built-in Anti-malware Software Works - How-To Geek:

https://www.howtogeek.com/217043/xprotect-explained-how-your-macs-built-in-anti-malware-works/

Startup in Safe Mode and test, then restart normal and re-test.

see > https://support.apple.com/en-us/HT201262

I'm having the same problem with the scroll feature of the mouse. Re-starting the iMac only fixes the problem temporarily. If I go back a few hours later, the mouse scroll isn't working again. Then I have to re-start the computer and problem solved. But the problem returns. PLEASE FIX THIS BUG AT ONCE! The problem started after I updated to the newest macOS, 12.0.1

I'm having the same issue. It also started when I updated to Monterey (hence it must be the culprit) and it happens every time I wake up the computer from sleep mode. The issue is only temporarily resolved after I restart it, but again, like other people here, it's only a temporary remedy. Is Apple aware of this issue and are they working to fix it? Does anyone know already the fix for this?

We have no idea what issues Apple may or may not be aware of. Always send feedback on your own so that they can get a better handle on the *scale* of the problem.

https://www.apple.com/feedback/

Gary you are not speaking to Apple on these forums, they are only our hosts. If you have a request of Apple post it at www.apple.com/feedback

Thanks, I've done that. Sent the bug report to Apple. I was enquiring whether anyone here has already a fix for this.

Hi, I turned my Mouse off and then turned it back on and now it works. Might give it a try.

There is an update to Monterey that fixes the scrolling problem.