Can I control my Mac with two mice simultaneously?

OB-Mike wrote:

Looking for two independent mice, as there will be two users and two monitors connected to the same Mac.

That will not work.

You can have 2 (or more) active user accounts, with the additional accounts accessing the Mac via Screen Sharing.

These additional users would need to be on their own Macs. They could be less powerful Macs, accessing a higher end Mac.

Or you could enable Screen Sharing to allow VNC access, then the additional users could use RealVNC Viewer on a Windows PC to login to the additional accounts.

Or RealVNC Viewer could be a Linux based PC, although that is a more complex setup.

You could connect many mice, but there will only ever be a single pointer.

no, only 1 cursor, never heard of any device / operating system, which could have more than one, would be a mess if they started to drag a window in each their direction.

OB-Mike wrote:

Looking for two independent mice, as there will be two users and two monitors connected to the same Mac.

Two users using the same Computer Account ?

As others have mentioned and agree with their assessments

Have to ask, though

Is this a hypothetical setup

Although this machine has only 1 Owner / Admin computer account

I can not Test your question beyond what has been illustrated earlier

That said

Try it yourself and report back

OB-Mike wrote:

How can I control my mac with two mouse devices simultaneously. i.e Two mice, two pointers, one mac

Interesting thought

But let us first mention

A M4 Mac Mini Pro may have come installed with macOS 15 Sequoia or possible macOS 26 Tahoe

Moving forwards with the 2 mice thing

Currently using a M4 Mac Mini ( not Pro ) with macOS 26.1 Tahoe

Have an Apple Magic Mouse 2 ( Bluetooth ) connected

Attached a cheap Logitech USB Mouse

If I use the Apple Mouse it works

If I use the Logitech USB mouse it works

Though, each Mouse does not work independent of the other