running slow

CMM may be the source of the problem, most experienced users on these forums consider CMM malware. Mac OS does not need nor does it benefit in ANY fashion by adding antivirus, cleaning or any other third party maintenance apps. If simply kept up-to-date and otherwise left alone Mac OS will run reliably and securely for most users for many years.

Please locate the developers uninstall instructions to get rid of CMM. If the problem persists, your description is a classic description of a failing HD. In that case, the next thing to do is to take the computer to your local Apple Store or independent Apple Authorized Service Provider to be diagnosed and repaired.

I haven't seen that long a run time without a failing disk warning.

Uninstall the cleaners and anti-virus crapware using the developer's instructions, CleanMyMac, Memory Clean Helper, AntiVirus One. No Anti-Virus software or so-called “cleaning” apps are needed or recommended for Mac OS. They can conflict with Mac's own built-in security. At best they will slow your Mac by using unnecessary resources and at worst will bork your entire system.

After that post another Etrecheck report.

I see another known performance killer:

3rd Party Preference Panes:
  Flash Player (installed 2019-11-22)
  Java (installed 2017-07-21)
 > Trusteer Endpoint Protection (installed 2018-09-18)

Trusteer has been trouble for a long time. I only see the Preference pane but it hints that others components may be present. See: https://www.ibm.com/support/trusteer/?lc=en_US

Your drive's write/read scores are low for a Fusion drive setup:

Performance:
  System Load: 1.45 (1 min ago) 1.14 (5 min ago) 1.12 (15 min ago)
  Nominal I/O speed: 0.89 MB/s
  File system: 54.90 seconds
  > Write speed: 93 MB/s
  > Read speed: 81 MB/s

Should be closer to 200MB/s if memory serves me (or not!). We have a geriatric 2011 iMac with a stock 3GBps 7200 rpm roto-drive that tests faster, up to 110MB/s.

Like others I would have you rerun EtreCheck after evicting all the dungware. I have seen cases here where drive scores increased once the poop was scooped. If they remain low, then you need to have the drive looked at by the pros.

Launch Daemons:
  [Loaded] com.macpaw.CleanMyMac4.Agent.plist (M
User Launch Agents:
  [Running] com.macpaw.CleanMyMac4.Updater.plist (MacPaw Inc. - installed 2020-01-10)

User Login Items:
  [Running] App Cleaner Helper (Sergiy Savenko - installed 2019-08-28)
    Modern Login Item
    /Applications/App Cleaner.app/Contents/Library/LoginItems/App Cleaner Helper.app

3rd Party Preference Panes:
  Java (installed 2017-07-21)
  Trusteer Endpoint Protection (installed 2018-09-18)

You still have the above from CMM and MacCleaner. You can use Finder menu > Go to folder to find and delete these items. I don't think you'll have mush luck with Launch Daemons the way Catalina locks the system, But the rest are accessible.

Yes, I meant to comment on how much faster it is your runtime is cut in half and the read & write speeds are much improved. Still something is causing it to run a bit slowly. Did you try a restart?

You might also try running DriveDx, which is more robust utility than Disk Utility to check the heath of your hard drive:

https://binaryfruit.com/drivedx

Your welcome, don't forget that other troublemaker Allan pointed out, Trusteer.

Yes, that's what I was afraid of. Good luck with it.